Deng, Wenwen published the artcileStructural characterization and hypolipidemic activities of purified stigma maydis polysaccharides, Application In Synthesis of 59-23-4, the main research area is stigma maydis polysaccharide hypolipidemic activity; bile acid‐binding; hyperlipidemia; poloxamer 407; stigma maydis polysaccharide.
This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP-1. This polysaccharide was composed of D-mannose, L-rhamnose, D-glucose, D-galactose, L-arabinose, D-xylose, and D-galacturonic acid, with a molar ratio of 1.00:0.21:1.41:1.44:0.70:0.44:0.56. The SMP-1 was mainly bonded by (1 → 6) and (1 → 3) linkages, with various monosaccharides being evenly distributed in the main and side chains. Moreover, SMP-1 had neither triple-helical structure nor mol. aggregation. Importantly, the SMP-1 could effectively bind the bile acids in vitro and significantly lower the total cholesterol, triglyceride, low-d. lipoprotein cholesterol levels, and moderately increase the high-d. lipoprotein cholesterol level in poloxamer 407-induced hyperlipidemic mice. Moreover, pretreatment with SMP-1 (≥300 mg/kg) could remarkably reduce fat accumulation and restore hepatocyte morphol. in the liver of hyperlipidemic mice. Altogether, these findings indicated that SMP-1 could be developed as a safe and effective food supplement for preventing and treating hyperlipidemic disorders.
Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.
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