Dimos, Nicole published the artcileCryoEM analysis of small plant biocatalysts at sub-2 Å resolution, COA of Formula: C10H18O, the main research area is Salvia borneol dehydrogenase BDH2 BDH1 cryo electron microscopy; borneol dehydrogenases; camphor; cryo-electron microscopy; green chemistry; high resolution; plant biocatalysts; terpenes.
Enzyme catalysis has emerged as a key technol. for developing efficient, sustainable processes in the chem., biotechnol. and pharmaceutical industries. Plants provide large and diverse pools of biosynthetic enzymes that facilitate complex reactions, such as the formation of intricate terpene carbon skeletons, with exquisite specificity. High-resolution structural anal. of these enzymes is crucial in order to understand their mechanisms and modulate their properties by targeted engineering. Although cryo-electron microscopy (cryoEM) has revolutionized structural biol., its applicability to high-resolution structural anal. of comparatively small enzymes has so far been largely unexplored. Here, it is shown that cryoEM can reveal the structures of plant borneol dehydrogenases of ∼120 kDa at or below 2 Å resolution, paving the way for the rapid development of new biocatalysts that can provide access to bioactive terpenes and terpenoids.
Acta Crystallographica, Section D: Structural Biology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.
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