Yu, Yongyi published the artcileChemistry and immunostimulatory activity of a polysaccharide from Undaria pinnatifida, Related Products of alcohols-buliding-blocks, the main research area is Undaria UPP2 monosaccharide cytokine cell proliferation immunostimulatory; Immunomodulatory activity; Polysaccharide; RAW264.7 cell; Structure; Undaria pinnatifida.
An immunol. active polysaccharide named as UPP-2 (1035.52 kDa) was isolated from Undaria pinnatifida using traditional water extraction followed by DEAE Sepharose fast flow chromatog. UPP-2 was proven to be a low sulfated polysaccharide with relatively abundant uronic acid (13.08 ± 0.67%). UPP-2 mainly consisted of xylose (64.55%), glucose (23.81%), arabinose (5.90%) and mannose (4.26%), and its main glycosidic linkage types included →2-α-D-Xylp-(1→, →4)-α-D-Glcp-1→, α-D-Xylp-(1→ and →2,4)-β-D-Xylp-1→. Results indicated that UPP-2 significantly promoted the proliferation and pinocytic capacity of RAW264.7 cells, and upregulated the mRNA expressions of iNOS, TNF-α, IL-6, and IL-1β at 100-600μg/mL with a maximum of 195, 42, 768, and 539 times those of the neg. control, resp. Moreover, UPP-2 significantly increased the secretions of nitric oxide, TNF-α and IL-6 at 100-600μg/mL (8.0, 73.1, and 188.7 times compared to those of the neg. control, resp.), as well as promoted the production of IL-1β obviously at 600μg/mL. Overall, UPP-2 could be served as a potential dietary supplement or functional food based on its immunostimulatory activity.
Food and Chemical Toxicology published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.
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