Adding a certain compound to certain chemical reactions, such as: 94022-96-5, 2-(Trifluoromethyl)phenethyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol
Example 67 3-(4-[2-(2-Trifluoromethyl-phenyl)-ethoxy]-indol-1-yl)-propionic acid (176) Prepared as described for Example 53 except the alkylation on the indole oxygen was completed in the following manner. 3-(4-Hydroxy-indol-1-yl)-propionic acid methyl ester (1.73 g, 7.89 mmol), triphenylphosphine (2.07 g, 7.89 mmol), and 2-(2-Trifluoromethyl-phenyl)-ethanol (1.25 mL, 7.89 mmol) were dissolved in tetrahydrofuran (35 mL). Diethyl azodicarboxylate (1.28 mL in 5 mL THF, 7.89 mmol) was added dropwise and the reaction stirred at room temperature overnight. The mixture was concentrated and purified by chromatography. Yield=290 mg, 10%. m.p.=126-129, THEORY: 63.66%; C, 4.81%; H, 3.71%; N. ACTUAL: 63.68%; C, 4.97%; H, 3.71%; N.
The synthetic route of 94022-96-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bigge, Christopher Franklin; Bridges, Alexander James; Casimiro-Garcia, Agustin; Fakhoury, Stephen Alan; Lee, Helen Tsenwhei; Reed, Jessica; Schaum, Robert; Schlosser, Kevin Matthew; Sexton, Karen; Zhou, Hairong; US2003/171377; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts