Rich, Jamie R. published the artcileChemical and chemoenzymatic synthesis of S-linked ganglioside analogs and their protein conjugates for use as immunogens, Category: alcohols-buliding-blocks, the main research area is Tetanus toxoid bovine serum albumin protein antigen vaccine immunogen; glycoprotein ganglioside synthesis coupling glycosyltransferase catalyzed immunogen glycosylation vaccine; hydrolase resistance glycoside antigen thioglycosidic linkage immunogenic antibody oligosaccharide; neuraminic acid ganglioside coupling disaccharide sphingosine glycosyltransferase catalyzed trisaccharide; sialic acid chemoenzymic synthesis ganglioside protein conjugate immunogen disaccharide.
Analogs of the tumor-associated gangliosides GM3 and GM2 containing terminal S-linked neuraminic acid residues and an amino terminated, truncated ceramide homolog have been synthesized and conjugated to a protein. The synthesis involved coupling of a S-linked sialyl α(2→3) galactose disaccharide with a glucosyl sphingosine analog, followed by elaboration and deprotection to give amino-terminated glycosyl ceramide. Glycosyltransferase-catalyzed extension of the trisaccharide provided access to the modified GM2 tetrasaccharide or sulfur-containing GD3 analog. Owing to their potentially enhanced resistance to endogenous exo-glycoside hydrolases and their inherent non-self character, carbohydrate antigens containing non-reducing terminal thioglycosidic linkages may be more immunogenic than O-linked antigens and may stimulate the production of antibodies capable of recognizing naturally occurring oligosaccharides. Our initial results suggest that in fact these antigens are viable immunogens and furthermore, that immune sera cross reacts with O-gangliosides in the context of a heterologous glycoprotein conjugate.
Chemistry – A European Journal published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Category: alcohols-buliding-blocks.
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