Flynn, Ryan A. published the artcileSmall RNAs are modified with N-glycans and displayed on the surface of living cells, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is small noncoding RNA N glycan glycoRNA Siglec receptor; RNA biology; glycoRNA; glycobiology; siglec; small RNAs.
Glycans modify lipids and proteins to mediate inter- and intramol. interactions across all domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge this view with evidence that mammals use RNA as a third scaffold for glycosylation. Using a battery of chem. and biochem. approaches, we found that conserved small noncoding RNAs bear sialylated glycans. These “”glycoRNAs”” were present in multiple cell types and mammalian species, in cultured cells, and in vivo. GlycoRNA assembly depends on canonical N-glycan biosynthetic machinery and results in structures enriched in sialic acid and fucose. Anal. of living cells revealed that the majority of glycoRNAs were present on the cell surface and can interact with anti-dsRNA antibodies and members of the Siglec receptor family. Collectively, these findings suggest the existence of a direct interface between RNA biol. and glycobiol., and an expanded role for RNA in extracellular biol.
Cell (Cambridge, MA, United States) published new progress about 28S rRNA Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts