Synthesis of pharmacophores containing a prolinate core using a multicomponent 1,3-dipolar cycloaddition of azomethine ylides was written by Selva, Elisabet;Castello, Luis M.;Mancebo-Aracil, Juan;Selva, Veronica;Najera, Carmen;Foubelo, Francisco;Sansano, Jose M.. And the article was included in Tetrahedron in 2017.Application of 65-22-5 The following contents are mentioned in the article:
Synthesis of pharmacophores containing a prolinate core, e.g. I, II, III and IV via silver acetate catalyzed multicomponent 1,3-dipolar cycloaddition reaction of heterocyclic aldehydes, amino esters and dipolarophiles was described. The preference of each tested amino esters toward different dipolarophiles was discussed. At the end, a selective reduction of an ester group allowed the preparation of dideoxiazanucleoside derivative V. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application of 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts