Related Products of 28539-02-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(100 mg, 0.49 mmol), benzotriazolemethanol (72 mg,0.49 mmol) and p-toluenesulfonic acid (10 mg, 0.05 mmol) were stirred for 6 h at the reflux in 10 mL toluene. The crude product was washed with an aqueous KOH solution (10%, 5 mL), dried under MgSO4 and, then, cooled overnight. Filtration and the consecutive solvent evaporation led to 146 mg of the yellow desired product (89% yield). 1H NMR (CDCl3) d: 8.05-7.35 (m, 4H), 6.11 (d, J = 6.9 Hz, 2H), 3.53-3.42 (m, 1H), 3.18-3.01 (m, 2H), 2.43-2.31 (m, 1H), 2.25 (t, J = 7.4 Hz, 2H), 1.87-1.30 m, 7H. 13C NMR (CDCl3) d: 173.39, 128.20, 124.56, 119.69, 111.07, 56.35, 50.90, 40.26, 38.60, 36.09, 34.62, 28.76, 24.96.. Anal. Calcd for C15H20N4OS2: C, 53.54; H, 5.99; N, 16.65; S, 19.06. Found: C, 53.66; H, 6.10; N, 16.16; S, 19.39; ESI-MS: m/z = 337.1 (M+H+); m/z = 359.1 (M+Na+); m/z = 695.3 (2M+Na+).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28539-02-8, 1-(Hydroxymethyl)benzotriazole.
Reference:
Article; De La Reberdiere, Arnaud; Lachaud, Fabien; Chuburu, Francoise; Cadiou, Cyril; Lemercier, Gilles; Tetrahedron Letters; vol. 53; 45; (2012); p. 6115 – 6118,4;,
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