Zhou, Yirong published the artcileA rhodium catalyzed cycloisomerization and tandem Diels-Alder reaction for facile access to diverse bicyclic and tricyclic heterocycles, Related Products of alcohols-buliding-blocks, the main research area is exocyclic diene preparation regioselective chemoselective; allenene cycloisomerization tandem Diels Alder rhodium catalyst; cyclic heterocyclic preparation regioselective chemoselective; dienophile allenene cycloisomerization tandem Diels Alder rhodium catalyst.
A regioselective distal cycloisomerization of 1,6-allenenes e.g., N-allyl-N-tosylbuta-2,3-dien-1-amine was successfully developed to afford six-membered ring exocyclic 1,3-dienes e.g., 3,4-dimethylene-1-tosylpiperidine employing a rhodium/diphosphine catalyst system. Deuterium labeling experiments and DFT calculations were performed to provide insights into the reaction mechanism of this unprecedented transformation. In addition, one-pot tandem Diels-Alder reactions with various dienophiles e.g., N-Ph maleimide could readily construct diverse bicyclic and tricyclic nitrogen heterocycles e.g., I, which are ubiquitous core scaffolds for a variety of natural products and bioactives. High efficiency and exclusive chemo and regioselectivities for a broad substrate scope were achieved under mild conditions using a low catalyst loading of 0.5 mol%.
Chemical Science published new progress about Chemoselectivity. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts