Klacsova, Maria published the artcileThermodynamic and structural study of DMPC-alkanol systems, Quality Control of 111-87-5, the main research area is thermodn structural property dimyristoylphosphatidylcholine alkanol system DSC.
The thermodn. and structural behaviors of lamellar dimyristoylphosphatidylcholine-alkanol (abbreviation DMPC-CnOH, n = 8-18 is the even number of carbons in the alkyl chain) systems were studied by using DSC and SAXD/WAXD methods at a 0-0.8 CnOH : DMPC molar ratio range. Up to n ≤ 10 a significant biphasic effect depending on the main transition temperature tm on the CnOH concentration was observed Two breakpoints were revealed: turning point (TP), corresponding to the min., and threshold concentration (cT), corresponding to the end of the biphasic tendency. These breakpoints were also observed in the alkanol concentration dependent change in the enthalpy of the main transition ΔHm. In the case of CnOHs with n > 10 we propose a marked shift of TP and cT to very low concentrations; consequently, only increase of tm is observed A partial phase diagram was constructed for a pseudo-binary DMPC-C12OH system. We suggest a fluid-fluid immiscibility of the DMPC-C12OH system above cT with a consequent formation of domains with different C12OH contents. At a constant CnOH concentration, the effects of CnOHs on ΔHm and bilayer repeat distance were found to depend predominantly on the mismatch between CnOH and lipid chain lengths. Observed effects are suggested to be underlined by a counterbalancing effect of interchain van der Waals interactions and head-group repulsion.
Physical Chemistry Chemical Physics published new progress about Bilayer films. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.
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