Ji, Xiang published the artcileSynthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization, Name: 2,2-Dimethoxyethanamine, the main research area is trifluoromethanesulfonamide trimethylsilyl triflate regioselective Pomeranz Fritsch cyclization; dihydroisoquinoline preparation.
Isoquinolines (IQs) and their derivatives are present in many natural products and biol. active small mols. Herein, we report a modified procedure for the classical Pomeranz-Fritsch protocol, which expands the scope of 1,2-dihydroisoquinoline (DHIQ) products. 1,2-DHIQs are an attractive branch point for the synthesis of IQs, but because of their innate reactivity, they have remained difficult to prepare We demonstrate that the Fujioka/Kita conditions, combining trimethylsilyl triflate (TMSOTf) and an amine base, activate dimethylacetals required for Pomeranz-Fritsch cyclization under sufficiently mild conditions to prepare a broad range of 1,2-DHIQ products. We also demonstrate the synthetic value of these DHIQs by further functionalization to either reduced tetrahydroisoquinoline (THIQ) or fully aromatized IQ natural products.
Journal of Organic Chemistry published new progress about Pomeranz-Fritsch cyclization (regioselective). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.
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