Faltracco, Matteo published the artcileDiastereoselective Synthesis of β-Lactams by Ligand-Controlled Stereodivergent Intramolecular Tsuji-Trost Allylation, Computed Properties of 22483-09-6, the main research area is diastereoselective intramol Tsuji Trost allylation ligand controlled stereodivergent; beta lactam stereoselective preparation.
The diastereoselective synthesis of highly substituted β-lactams by intramol. Tsuji-Trost allylation is reported. Judicious selection of the ligand on palladium allows selective access to either the trans isomer (in generally good to excellent yield with very high diastereomeric excess) or cis isomer (with yields and diastereoselectivity ranging from modest to excellent depending on the substrate). The reaction proceeds under exceedingly mild conditions (rt, no additives) with a broad range of substrates, which are readily accessible by the Ugi reaction.
Journal of Organic Chemistry published new progress about Diastereoselective synthesis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.
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