Adebomi, Victor published the artcileMetal-free selective modification of secondary amides: Application in late-stage diversification of peptides, Formula: C4H11NO2, the main research area is peptide solid phase synthesis twisted amide diversification metal free; carbon nitrogen bond activation DFT ground state rotational energy; transamidation esterification thiocarbonyl insertion reaction thiocarbonylation solid support; mol structure twisted amino acid.
Here we solve a long-standing challenge of the site-selective modification of secondary amides and present a simple two-step, metal-free approach to selectively modify a particular secondary amide in mols. containing multiple primary and secondary amides. D. functional theory (DFT) provides insight into the activation of C-N bonds. This study encompasses distinct chem. advances for late-stage modification of peptides thus harnessing the amides for the incorporation of various functional groups into natural and synthetic mols.
Organic Letters published new progress about Amino acids Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Formula: C4H11NO2.
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