Fujii, Kahori’s team published research in Chemical & Pharmaceutical Bulletin in 2015-05-31 | CAS: 64519-82-0

Chemical & Pharmaceutical Bulletin published new progress about Carbohydrates Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), THU (Therapeutic Use), PROC (Process), BIOL (Biological Study), USES (Uses). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, HPLC of Formula: 64519-82-0.

Fujii, Kahori published the artcilePhysical characterization of meso-erythritol as a crystalline bulking agent for freeze-dried formulations, HPLC of Formula: 64519-82-0, the main research area is meso erythritol crystal filler freeze drying cooling crystallization.

The purpose of this study was to identify and characterize new crystalline bulking agents applicable to freeze-dried pharmaceuticals. Thermal anal. of heat-melt sugar and sugar alc. solids as well as their frozen aqueous solutions showed high crystallization propensity of meso-erythritol and d-mannitol. Exptl. freeze-drying of the aqueous meso-erythritol solutions after their cooling by two different methods (shelf-ramp cooling and immersion of vials into liquid nitrogen) resulted in cylindrical crystalline solids that varied in appearance and microscopic structure. Powder X-ray diffraction and thermal anal. indicated different crystallization processes of meso-erythritol depending on the extent of cooling. Cooling of the frozen meso-erythritol solutions at temperatures lower than their Tg’ (glass transition temperature of maximally freeze-concentrated phase, -59.7°C) induced a greater number of nuclei in the highly concentrated solute phase. Growth of multiple meso-erythritol anhydride crystals at around -40°C explains the powder-like fine surface texture of the solids dried after their immersion in liquid nitrogen. Contrarily, shelf-ramp cooling of the frozen solution down to -40°C induced an extensive growth of the solute crystal from a small number of nuclei, leading to scale-like patterns in the dried solids. An early transition of the freezing step into primary drying induced collapse of the non-crystalline region in the cakes. Appropriate process control should enable the use of meso-erythritol as an alternative crystalline bulking agent in freeze-dried formulations.

Chemical & Pharmaceutical Bulletin published new progress about Carbohydrates Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), THU (Therapeutic Use), PROC (Process), BIOL (Biological Study), USES (Uses). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, HPLC of Formula: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts