115-20-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115-20-8 as follows.
Carbon monoxide was bubbled through a solution of 11′- iodovinorelbine (151 mg, 0.167 mmol), triethylamine (169 mg, 1.67 mmol) and bis (triphenylphosphine) palladium (II) dichloride (23 mg, 0.033 mmol) in a mixture of DMF/2,2, 2-trichloroethanol (4 mL, 1 : 1) for 5 min. The reaction mixture was heated at 50 C for 14 h under one atmosphere of carbon monoxide (balloon). The solution was diluted with ethyl acetate (35 mL) then washed with saturated NaHC03 (2 x 20 mL) and brine (20 mL), dried over MgS04, and evaporated to dryness in vacuo. The residue was purified by reverse phase chromatography (C18, acetonitrile/water, 0.05% TFA) to provide 11′- (2,2, 2-trichloroethoxycarbonyl) lvinorelbine Trifluoroacetate (78 mg, 40% yield) as a white powder after lyophilization
The chemical industry reduces the impact on the environment during synthesis 115-20-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AMR TECHNOLOGY, INC.; WO2005/55943; (2005); A2;,
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