Synthetic Route of 3513-81-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3513-81-3, name is 2-Methylenepropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.
Step lb : Compound of formula 1-3: R_ = H and Rl = t-Bu :; To a solution of 2-methylene-1, 3-propane diol (5. 28g, 0.06 mmol) and di-tert-butyl dicarbonate (35 g, 0.16 mol) in 150 ml of dichloromethane was added 6N NaOH (70 ml) and tetrabutylammoniahydrogensulfate (3.4 g, 10 mmol). The mixture was stirred at room temperature overnight. The organic layer was separated, washed with NaHC03 (200 ml x 3) and brine (200 ml), dried over anhydrous MgSO4, concentrated and dried over vacuum to give the title compound. ‘H NMR (CDC13) : 5. 20 (s, 2H) ; 4.44 (s, 4H) ; 1.18 (s, 18H). 13C NMR (CDCl3) : 8 153. 3, 138. 5,117. 3,82. 3,66. 9,27. 8.
According to the analysis of related databases, 3513-81-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2003/97659; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts