Perez, Maria published the artcileSynthesis of novel glycoconjugates and evaluation as inhibitors against β-glucosidase from almond, SDS of cas: 2595-07-5, the main research area is hydrolase glucosidase inhibition glycoside glycoconjugate preparation disaccharide structure activity; amino glycoside disaccharide preparation glucosidase inhibitor glycoconjugate glucosaminide lactose.
Hydrolytic activity of glycosidases can be influenced by inhibitors of glycosidic nature. We have synthesized glycoconjugates consisting of galactose, glucosaminide or lactose 1-O-linked with allyl alc., pentenol or tetra-ethylene-glycol moieties. These compounds were found to be inhibitors of the hydrolase activity of the β-glucosidase from almond, with Ki in the range of 7.7-107 mM and presenting different types of inhibition. Based on the structure of the functionalized glycosides and the inhibition studies performed, we suggest that the nature of the carbohydrate is determinant in the inhibitory strength of these glycoconjugates.
Journal of Molecular Catalysis B: Enzymatic published new progress about Disaccharides Role: BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, SDS of cas: 2595-07-5.
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