Siezen, Roland J. published the artcilePermanent suppression of phase separation cataract in calf lens using amine modification agents, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biochemical and Biophysical Research Communications (1985), 133(1), 239-47, database is CAplus and MEDLINE.
Low-temperature-induced opacification (cold cataract) of the nucleus of young mammalian lenses was associated with a phase separation of proteins in the lens cell cytoplasm. Calf lenses were treated with a variety of imidoesters and N-hydroxysuccinimide esters, which react specifically with amino groups. Many potent inhibitors of phase-separation cataract were identified which lower the opacification temperature by ≥6°. Lenses generally remained clear, colorless and soft. Furthermore, suppression of the cold-cataract temperature was permanent upon removal of excess reagent.
Biochemical and Biophysical Research Communications published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C7H14N4, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.
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