Watts, Norman R. M. published the artcileAnalysis of near-neighbor contacts in bacteriophage T4 wedges and hubless baseplates by using a cleavable chemical cross-linker, Related Products of alcohols-buliding-blocks, the publication is Journal of Virology (1989), 63(6), 2427-36, database is CAplus and MEDLINE.
Although bacteriophage T4 baseplate morphogenesis has been analyzed in some detail, there is little information available on the spatial arrangement and associations of its 150 subunits. Therefore, anal. of its near-neighbor interactions by using the cleavable chem. cross-linker ethylene glycobis(succinimidylsuccinate) was carried out. The cross-linked complexes that have been identified in the one-sixth arms or wedges and also in baseplatelike structures called rings are described which consist of 6 wedges but lack the central hub, both of which are purified from T4 gene 5–-infected cells. Thirty different complexes were identified, of which about half contain multimers of a single species and half contain 2 different species. In general, the complexes reflect and support the assembly pathway derived by Y. Kikuchi and J. King (1975 ), but broaden its scope to include such complexes as gp25-gp53, gp25-gp48, and gp48-gp53, which locate the gp48 binding site over the inner edge of the ring but outside the central hub. The data also supports the view that wedges are assembled from the outer edge inward toward the central hub. Wedge-wedge contact in rings was mediated primarily by gp12 and gp9, the absence of which dramatically destabilized the ring ↔ wedge equilibrium in favor of wedges. Although no heterologous complexes containing gp9 were identified, gp12 contacts unique to rings were observed with both gp10 and gp11.
Journal of Virology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H19ClN4, Related Products of alcohols-buliding-blocks.
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