Lemke, Carina published the artcileChromenones as Multineurotargeting Inhibitors of Human Enzymes, Synthetic Route of 622-40-2, the publication is ACS Omega (2019), 4(26), 22161-22168, database is CAplus and MEDLINE.
The complex nature of multifactorial diseases, such as Morbus Alzheimer, has produced a strong need to design multitarget-directed ligands to address the involved complementary pathways. A purposive structural modification of a tetratarget small-mol. contilisant and generated a combinatorial library of substituted chromen-4-ones I (R = pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, etc.; n = 2, 3, 4, 5) is reported. The compounds comprise a basic moiety which is linker-connected to the 6-position of the heterocyclic chromenone core. The syntheses were accomplished by Mitsunobu- or Williamson-type ether formations. The resulting library members were evaluated at a panel of seven human enzymes, all of which being involved in the pathophysiol. of neurodegeneration. A concomitant inhibition of human acetylcholinesterase and human monoamine oxidase B, with IC50 values of 5.58 and 7.20 μM, resp., was achieved with the dual-target 6-(4-(piperidin-1-yl)butoxy)-4H-chromen-4-one.
ACS Omega published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts