Related Products of 2854-16-2 , The common heterocyclic compound, 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of the compound (53 mg, 0.1 mmol) obtained in Reference Example 28 in dichloromethane (2 mL) were added 1-amino-2-methylpropan-2-ol (18 mg, 0.2 mmol) and PyBOP [registered trade mark, benzotriazol-1-yl-oxy-tris(pyrrolidino)phosphonium hexafluorophosphate (benzotriazal-1-yl-oxy-tris(pyrrolidino)phosphonium hexafluorophosphate)] (52 mg, 0.1 mmol), and the mixture was stirred at room temperature.After 16 hr, 10percent aqueous citric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate.The organic layer was extracted, washed with water and saturated brine, and dried over sodium sulfate.After concentration under reduced pressure, the residue was purified by silica gel column (chloroform:methanol=100:0 – 98:2) to give the object product (51 mg, 89percent).The product was dissolved in ethyl acetate (1 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (1 ml, 4 mmol) was added thereto, and the mixture was stirred at room temperature.After 14 hr, the mixture was concentrated under reduced pressure.To the obtained residue was added 2 mol/L aqueous sodium hydroxide solution, and the mixture was extracted with chloroform.The organic layer was extracted, washed with saturated brine, and dried over sodium sulfate.After concentration under reduced pressure, the residue was purified by silica gel column (chloroform :methanol=100:0 – 95:5) to give the object product (32 mg, 76percent).1H-NMR (CDCl3) delta 1.10(t, J = 7.0Hz, 3H), 1.29(s, 6H), 1.36(d, J = 6.8Hz, 3H), 3.21(dd, J= 5.3, 3.6Hz, 1H), 3.29-3.51(m, 4H), 3.61-3.73(m, 2H), 3.97(d, J = 14.3Hz, 1H), 4.11(d, J = 14.3Hz, 1H), 4.21(dt, J = 15.3, 4.2Hz, 1H), 4.33(m, 1H), 6.90-7.07(m, 6H), 7.68(dd, J = 8.3, 0.9Hz, 1H), 7.83(brt, J = 6.0Hz, 1H).
The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP2380881; (2011); A1;,
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