Shu, Bing published the artcileSyntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation, SDS of cas: 622-40-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(16), 2036-2039, database is CAplus and MEDLINE.
We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 (I) could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis.
Chemical Communications (Cambridge, United Kingdom) published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H4ClNO2, SDS of cas: 622-40-2.
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