Newman, Melvin S. published the artcilegem-Dialkyl effect in medicinal agents, Quality Control of 39943-41-4, the publication is Journal of Medicinal Chemistry (1972), 15(10), 1003-6, database is CAplus and MEDLINE.
Modification of various drugs (cholinergic agonists and antagonists, ganglionic blockers, antihistamines, local anesthetics) containing a dialkylaminoethoxy group R2N(CH2)2O by insertion of a gem-dialkylmethylene group, forming R2NCH2CR12CH2O, did not produce progressive changes in activity related to the nature of the gem-dialkyl substituents. The gem-dialkyl substituents used were Me, Et, and cycloalkyl (cyclopropyl to cyclohexyl). Varying these substituents altered the distance between N and O atoms in the alkanolamine group, which was evidently not an important parameter for activity.
Journal of Medicinal Chemistry published new progress about 39943-41-4. 39943-41-4 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-((Dimethylamino)methyl)cyclopropyl)methanol, and the molecular formula is C7H15NO, Quality Control of 39943-41-4.
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