Electric Literature of 627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.
IMB105 (1.0g, 2.5mmol), 2-bromoethanol (0.22mL, 3.0mmol) or 3-chloropropanol (0.25mL, 3.0mmol), and PPh3 (1.3g, 5.0mmol) were added to dried THF (20mL) under Ar2. The obtained solution was cooled on an ice-water bath. DEAD (2.0mL, 4.25mmol, 40% in tulene) was added to the solution, and the reaction mixture was then allowed to warm to room temperature and stirred for 12h. The solvent was removed in vacuo, and the obtained residue was extracted into ethyl acetate (100mL). The organic layer was washed consecutively with water (50mL), brine (50mL), dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified on silica gel using Petroleumether (60-90C)/ethyl acetate in different proportions to afford 5 or 6.
According to the analysis of related databases, 627-30-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Gu, Yuxi; Hu, Laixing; Liu, Yonghua; Sun, lianqi; Wu, Yanbin; European Journal of Medicinal Chemistry; vol. 191; (2020);,
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