Luescher, Michael U.’s team published research in Synlett in 30 | CAS: 96-20-8

Synlett published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Formula: C4H11NO.

Luescher, Michael U. published the artcileEvidence for a Radical Mechanism in Cu(II)-Promoted SnAP Reactions, Formula: C4H11NO, the publication is Synlett (2019), 30(4), 464-470, database is CAplus.

Saturated nitrogen heterocycles could be found with increasing abundance in bioactive mols. despite a limited number of methods to access these scaffolds. However, the coupling of recently introduced SnAP [tin (Sn) amine protocol] reagents with a wide range of aldehydes and ketones had proven to be a reliable, practical, and versatile one-step approach to saturated N-heterocycles, e.g., I. While effective, the lack of mechanistic understanding limits efforts to develop new catalytic and enantioselective variants. To distinguish between a polar or radical mechanism, Lewis and Bronsted acids, radical trapping experiments, and radical clock SnAP reagents were assessed reinforcing the current understanding of the SnAP protocol as a radical cyclization.

Synlett published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts