Sharma, Kamna published the artcileDevelopment and Validation of UV-Spectrophotometric and RP-HPLC Methods for Simultaneous Estimation of Fexofenadine Hydrochloride, Montelukast Sodium and Ambroxol Hydrochloride in Tablet Dosage Form, Related Products of alcohols-buliding-blocks, the publication is Analytical Chemistry Letters (2018), 8(6), 829-843, database is CAplus.
A UV-spectrophotometric and RP-HPLC method was developed and validated for concurrent estimation of fexofenadine hydrochloride (FEX), montelukast sodium (MLK) and ambroxol hydrochloride (AMB). In RP-HPLC chromatog., the retention time for FEX, MLK and AMB was 2.775 min, 9.529 min and 5.261 min, resp. and detection at max 210 nm for all three of drugs (overlain spectra). Linear regression anal. shows a good linear relationship; in the concentration range of 10-30, 10-50 and 5-25μg/mL; for FEX, MLK and AMB with r2 > 0.999. The UV-spectrophotometric estimation was done by two methods; zero order and first derivative method. These methods were based on the measurement of absorbance at 220.20, 283.42 and 245.84 nm in zero order; 221, 287.52 and 262.25 nm in first order derivative method. In both UV methods, the drugs follow the Beer-Lambert’s law in the concentration range of 6-26, 4-24 and 8-28μg/mL, resp. showing correlation coefficient r2 > 0.999. The RP-HPLC and UV methods showed good reproducibility and recovery with the percent relative standard deviation (RSD) less than 5%. These methods were successfully applied for reliable quantification of FEX, MLK and AMB in a com. and routine anal. in combined dosage form.
Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C4H6O3, Related Products of alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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