Ben Khemis, Ismahene published the artcileAdsorption of 2-phenylethanethiol on two broadly tuned human olfactory receptors OR1A1 and OR2W1: Interpretation of the effect of copper ions via statistical physics monolayer adsorption model, Safety of 2-Phenylethanethiol, the publication is Journal of Molecular Liquids (2021), 116926, database is CAplus.
This paper aims to investigate the effect of metal especially copper ions on the adsorption of a key food odorant (2-phenylethanethiol) on two human olfactory receptors OR1A1 and OR2W1 that was interpreted via a statistical physics monolayer model. To this purpose, four exptl. dose-olfactory response curves were used without and with the presence of Cu2+ for each human receptor. In order to reach a theor. interpretation of the exptl. data and understand the effect of the used metal on adsorption process introduced on the olfaction mechanism, a statistical physics monolayer adsorption model with identical and independent sites was applied. The used model showed that the presence of copper ions decreased the efficacy (olfactory response at saturation) of 2-phenylethanethiol key food odorant activating OR1A1, suggesting a neg. allosteric action. However, the presence of Cu2+ reduced the potency (concentration at half saturation) of the studied thiol key food odorant in activating OR2W1, suggesting an orthosteric competitive action. Furthermore, the molar adsorption energies retrieved from data anal. varied from 5.568 to 9.886 kJ/mol in studied systems, whose values showed that the process based on a phys. adsorption. Lastly, the dose-olfactory response curves of 2-phenylethanethiol on two broadly tuned human olfactory receptors OR1A1 and OR2W1 provided access to the olfactory receptor site size distribution (RSD) and also the adsorption energy distribution (AED).
Journal of Molecular Liquids published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts