Braude, M. B. published the artcileChemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil, SDS of cas: 3818-50-6, the publication is Khimiko-Farmatsevticheskii Zhurnal (1975), 9(10), 12-14, database is CAplus.
I (R = H, 4-Cl, 2-MeCO2, 4-Me; X = CO2, OCH2CO2, CO; R1 = Ph, 2,3,5-HO(Ac)(Cl)C6H2, CH2COPh; A = Cl, p-ClC6H4SO3, iodo, hydroxynaphthoate) were prepared in 56.5-100% yield by standard methods. RCO2CH2CH2NMe2 (R = Ph, p-ClC6H4, p-ClC6H4OCH2) were prepared in 88-95% yield. I (R = H, X = CO2, R1 = Ph, 2,3,5-HO(Ac)(Cl)C6H2) at 0.4-0.6 g/kg in mice infected with Trichocephalus muris were less effective and more toxic than neftamon and difezil. The introduction of an acetoxy group in position 2 and a halo group in position 4 lowered the toxicity and effectiveness.
Khimiko-Farmatsevticheskii Zhurnal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.
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