The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-86-7, name is 2-Methyl-1-phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
At 15C a solution of 380 g (2,53 mol) 2-methyl-1 -phenyl-propan-2 -ol and 426 g (4,3 mol) ethyl cyanoformate in 500 ml cyclohexane has been added to a mixture of 500 ml cyclohexane and 1899 g (19 mol) concentrated sulfuric acid upon stirring. After ca. 15 min the reaction mixture was poured onto an ice/water mixture and cautiously basified upon addition of concentrated NaOH-solution. The phases were separated and the aqeous layer was extracted twice with me- thyl-t-butylether. The combined organic phases were dried over sodium sulfate and ant volatiles were evaporated to yield 584 g (99 %) ethyl 3,3-dimethyl-4H-isoquinoline-1-carboxylate as a yellow oil. 1H-NMR (CDCIs, d in ppm): 7,55 (d, 1H); 7,4 (t, 1H); 7,3 (t, 1H); 7,18 (d, 1H); 4,45 (q, 2H); 2,75 (s, 2H); 1,4 (t, 3H); 1,28 (s, 6H)
With the rapid development of chemical substances, we look forward to future research findings about 100-86-7.
Reference:
Patent; BASF SE; RACK, Michael; MUELLER, Bernd; (38 pag.)WO2019/145177; (2019); A1;,
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