Velasco, C. published the artcileEffects of the nuclear factor-κB inhibitors 2-hydroxy-4-trifluoromethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder, Formula: C8H5F3O3, the publication is Journal of Urology (Hagerstown, MD, United States) (2001), 166(5), 1962-1968, database is CAplus.
We examined the effects of i.v. administration of the 2 nuclear factor-κB inhibitors aspirin and 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) on bladder filling and voiding in anesthetized and conscious rats. Disappearance of isovolumic bladder contractions after i.v. administration of different doses of aspirin and HTB in anesthetized, transurethrally catheterized rats was evaluated. Cystometry was performed in conscious rats during bladder infusion with saline or diluted acetic acid as well as in those with cyclophosphamide induced cystitis. Changes in bladder capacity and voiding pressure were evaluated after i.v. administration of test compounds Aspirin induced a dose dependent disappearance of isovolumic bladder contractions in anesthetized rats with an extrapolated dose of 2.1 mg./kg. inducing 10 min of bladder quiescence. HTB was practically inactive, inducing a dose independent block of 3 to 4 min after i.v. administration of 1 to 10 mg./kg. In conscious rats with a bladder infused with saline aspirin was poorly active on bladder capacity, inducing a 20% increase 60 min after i.v. administration of 30 and 100 mg./kg. In rats with a bladder infused with acetic acid aspirin was much more active when injected at the initiation of inflammation and after 1 h of irritant infusion. In this latter situation aspirin increased bladder capacity up to 60% after i.v. administration of 30 and 100 mg./kg. Similar results were obtained in rats with cyclophosphamide induced cystitis in which the bladder was infused with saline. In these cystometrog. models 30 mg./kg. HTB i.v. was completely inactive. The results show that HTB is devoid of significant effects on the micturition reflex in the absence or presence of bladder inflammation, suggesting that acute inhibition of nuclear factor-κB does not influence bladder urodynamics in rats. In contrast, aspirin, which is a cyclooxygenase and nuclear factor-κB inhibitor, was always effective, indicating the important role of cyclooxygenase enzymes.
Journal of Urology (Hagerstown, MD, United States) published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C14H10O4, Formula: C8H5F3O3.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
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