Mao, Di published the artcileA Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures, Recommanded Product: 3-(Methylamino)phenol, the publication is Angewandte Chemie, International Edition (2017), 56(7), 1765-1770, database is CAplus and MEDLINE.
A major hurdle in stem cell therapy is the tumorigenic risk of residual undifferentiated stem cells. This report describes the design and evaluation of synthetic hybrid mols. that efficiently reduce the number of human induced pluripotent stem cells (hiPSCs) in cell mixtures The design takes advantage of Kyoto probe 1 (KP-1), a fluorescent chem. probe for hiPSCs, and clin. used anticancer drugs. Among the KP-1-drug conjugates we synthesized, we found an exceptionally selective, chem. tractable mol. that induced the death of hiPSCs. Mechanistic anal. suggested that the high selectivity originates from the synergistic combination of transporter-mediated efflux and the cytotoxicity mode of action. The present study offers a chem. and mechanistic rationale for designing selective, safe, and simple reagents for the preparation of non-tumorigenic clin. samples.
Angewandte Chemie, International Edition published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Recommanded Product: 3-(Methylamino)phenol.
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