A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging was written by Yin, Cai-Xia;Qu, Li-Jun;Huo, Fang-Jun. And the article was included in Chinese Chemical Letters in 2014.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
A pyridoxal-based chemosensor (I) was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were studied in a methanol: HEPES solution The compound displayed selectivity for Cu2+, as evidenced by a colorless to yellow color change, which was characterized using UV-visible spectroscopy. The fluorescence of the compound can be quenched only by Cu2+, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts