Anticonvulsant activity of 2,2-disubstituted 1,3-propanediols in electroshock seizures was written by Berger, F. M.. And the article was included in Proceedings of the Society for Experimental Biology and Medicine in 1951.Name: 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:
cf. C.A. 45, 265a. Compounds studied were, 2,2-dimethyl-, 2,2-diethyl-, 2,2-dipropyl-, 2-butyl-, 2,2-dibutyl-, 2-ethyl-2-methyl-, 2-isopropyl-2-methyl-, 2-propyl-2-methyl-, 2-butyl-2-methyl-, 2-butyl-2-ethyl-, 2-ethoxy-2-ethyl-, 2-ethyl-2-phenyl-, 2-phenyl-, 2,2-diphenyl-, 2-phenoxy-2-phenyl-, and 2,2-dibenzyl-1,3-propanediol. All compounds in suitable doses protected mice against electroshock convulsion. The mol. configuration favorable for maximum activity is the presence of a quaternary C atom to which 1 or 2 Ph radicals are attached. Several of the compounds were about as potent as mephenesin. The most potent (the diphenyl derivative) was about 1/6 as potent as Na phenobarbital. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Name: 2-Butyl-2-ethylpropane-1,3-diol).
2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2-Butyl-2-ethylpropane-1,3-diol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts