Electric Literature of 27489-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: The amino alcohol was dissolved in CH2Cl2(1 M) followed by addition of Et3N (2.5 equiv) and the resultingmixture stirred at room temperature for 30 min. Then, a solution of o-nitrobenzenesulfonyl chloride (0.85 equiv)in CH2CL2 (0.85 M) was added slowly and the reaction mixture stirred for 3 h.The reaction was followed by TLC (3% MeOH/ CH2Cl2) andquenched with a 1M HCl solution. Following aqueous phase extraction with CH2Cl2(3 ),the combined organic layers were washed with brine and dried over MgSO4.The solvent was removed under reduced pressure and the crude product purified byflash chromatography on silica gel with 100% Et2O (2a) or 3% MeOH/ CH2Cl2(2b-g) to afford the desiredcompound.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.
Reference:
Article; Vezina-Dawod, Simon; Derson, Antoine; Biron, Eric; Tetrahedron Letters; vol. 56; 2; (2015); p. 382 – 385;,
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