As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 2002-24-6
A mixture of crude 1- (3- {4- [3-CHLORO-4- (3-FLUORO-BENZYLOXY)-PHENYLAMINO]-QUINAZOLIN- 6-yl}-prop-2-ynyl)-2-phenyl-N-cyano-isourea (70 mg, 0.12 mmol) (from Step H, Example 1), 2- HYDROXYETHYLAMINE hydrochloride (39 mg, 0.4 mmol) and triethylamine (0.07 mL, 0.5 mmol) in isopropanol (2 mL) was heated to 85C in a sealed tube. The reaction was cooled to room temperature after 3 hours. Solvent was removed via rotovap. The residue was then purified by FCC to give the final product (25 mg, 38%) as a light yellow solid. MS ESI (+) m/z 544 (M+1) detected ; 1H NMR (400 MHz, deuterated DMSO) 9.95 (s, 1H), 8.7 (s, 1H), 8.6 (s, 1H), 8.05 (s, 1H), 8.0 (s, 1H), 7.8 (m, 1H), 7. 78 (M, 2H), 7.6 (br, 1H), 7. 5 (M, 1H), 7.22-7. 4 (M, 2H), 7.2 (M, 1H), 7.1 (M, 1H), 5.25 (s, 2H), 4.25 (m, 2H),-3. 5 (m, 2H), 3.25 (M, 2H).
The chemical industry reduces the impact on the environment during synthesis 2002-24-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ARRAY BIOPHARMA, INC.; WO2004/46101; (2004); A2;,
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