Synthesis, characterisation and antibacterial activity of benzohydrazones derived from 3-hydroxy-5-hydroxymethyl-2-methylpyridine-4-carboxaldehyde was written by Ramdas, Kavitha;Sireesha, B.;Reddy, Ch. Venkata Ramana. And the article was included in Heterocyclic Letters in 2016.HPLC of Formula: 65-22-5 The following contents are mentioned in the article:
New Schiff bases I [R = 4-OH, 4-Cl, 4-Br, etc.] derived from 3-hydroxy-5-hydroxymethyl-2-methylpyridine-4-carboxaldehyde were synthesized and characterized by various spectro-anal. techniques like IR, 1H-NMR, 13C-NMR and mass spectroscopy. The compounds I were screened for their antibacterial activity against Gram neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram pos. bacteria (Staphylococcus aureus and Bacillus cereus). Compounds I [R = 2,4-di-Cl] and [R = 3,4,5-tri-MeO] showed excellent antibacterial activity while compounds I [R = 4-OH, 4-F, 3-O2N] showed good activity. The remaining compounds exhibited moderate activity. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5HPLC of Formula: 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts