Liquid chromatographic resolution of 1,1′-bi-2-naphthol and 3,3′-diaryl-1,1′-bi-2-naphthols on Pirkle-type chiral stationary phases based on leucine and phenylglycine was written by Hyun, Myung Ho;Kim, Kwang Soo;Cho, Yoon Jae. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2005.Application In Synthesis of (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol The following contents are mentioned in the article:
Pirkle-type chiral stationary phases (CSPs) based on (S)-leucine and (S)-phenylglycine were applied in the resolution of 1,1′-bi-2-naphthol and 3,3′-diaryl-1,1′-bi-2-naphthols. Among the two Pirkle-type CSPs, the one based on (S)-N-(3,5-dinitrobenzoyl)leucine N-propylamide is excellent and most widely applicable. The elution orders for the resolution of 1,1′-bi-2-naphthol on the CSPs based on (S)-N-(3,5-dinitrobenzoyl)leucine N-propylamide and (S)-N-(3,5-dinitrobenzoyl)phenylglycine N-propylamide were opposite to those for the resolution of 3,3′-diaryl-1,1′-bi-2-naphthols. To rationalize the reversed elution orders, the authors proposed two different chiral recognition mechanisms based on the chromatog. resolution behaviors, with the aid of the CPK mol. model study. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Application In Synthesis of (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol).
(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts