In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 862135-61-3, name is 5-Bromoindan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 862135-61-3
To a solution of NaH (60%, 160 mg, 3.99 mmol) in dry THF (5 mL) at 0 C. was added a solution of 5-bromo-2,3-dihydro-1H-inden-2-ol (500 mg, 2.347 mmol) in dry THF (5 mL). The resulting solution was stirred for 30 min at 0 C. Benzyl bromide (0.335 mL, 2.82 mmol) was added and the solution was stirred at 25 C. for 15 h. The mixture was quenched by saturated, aqueous ammonium chloride (10 mL), which was extracted with EtOAc (40 mL¡Á3). The combined organic layers were washed by brine (15 mL¡Á3) and concentrated to give the crude product, which was purified by silica gel chromatography (1:0-10:1 petroleum ether: EtOAc) to afford the title compound. 1H NMR (400 MHz, CDCl3): delta 7.25-7.37 (7H, m), 7.07 (1H, d, J=8.0 Hz), 4.57 (2H, s), 4.38-4.47 (1H, m), 2.95-3.23 (4H, m).
The synthetic route of 862135-61-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
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