A derivatisation agent selection guide was written by Tobiszewski, Marek;Namiesnik, Jacek;Pena-Pereira, Francisco. And the article was included in Green Chemistry in 2017.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:
The study reported herein is aimed at the greenness assessment of 267 derivatization agents that are frequently applied in anal. chem. and related disciplines. Multicriteria decision anal. allowed obtaining three rankings of derivatization agents applied in liquid chromatog., gas chromatog. and chiral anal. The criteria of assessment included the safety information obtained from material safety data sheets and physicochem. and environmental parameters predicted with relevant models. As for some of the agents predicted data were not available, these agents were assessed with a smaller number of criteria, within the ranking of low confidence. The results of the study will help to apply greener derivatization agents, wherever the green chem. principle of avoiding derivatization cannot be fulfilled. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C8H10ClNO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts