Application of 4654-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.
A solution of methane sulfonyl chloride (12.8 ml, 165.8 mmol, 1.1 eq) in methylisobutylketone (MIBK) (40 ml) was added dropwise to a cooled (5-10C) solution of bromophenethyl alcohol 12 (30.3 g, 150.7 mmol) and triethylamine (23.1 ml, 165.8 mmol, 1.1 eq) in MIBK (300 ml) an argon atmosphere within ca. 1 hour. Then, the reaction mixture was left to slowly heat up to the room temperature for ca. 2 h. After a check of the reaction by means of HPLC the reaction suspension was processed by addition of diluted aqueous HC1 (37 ml of 1M HC1 + 100 ml of H20) and intensively stirred for 15 min to achieve mixing of the phases; after stabilization and separation the aqueous phase was removed and the organic phase was still washed with 5% aqueous NaHC03 (50 ml), H20 ( 100 ml) and brine (100 ml). The crude mesylate solution was then heated up to boil under an argon atmosphere and dried by azeotropic distillation (ca. 50 ml of the H 0-MIBK mixture removed by distillation
The chemical industry reduces the impact on the environment during synthesis 4654-39-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ZENTIVA, K.S; ZEZULA, Josef; HAJICEK, Josef; WO2014/26657; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts