Virtual screening of molecular properties of chitosan and derivatives in search for druggable molecules was written by Hassan, Basila;Shireen, Ajmala;Muraleedharan, K.;Mujeeb, V. M. Abdul. And the article was included in International Journal of Biological Macromolecules in 2015.SDS of cas: 65-22-5 The following contents are mentioned in the article:
Druggability of chitosan monomer and Schiff bases as well as reduced Schiff base derivatives of chitosan were examined Oral bioavailability and bioactivity of all these mols. against selected drug targets as well as ADME/Tox studies were conducted. All the mols. satisfied Lipinski’s rule of five confirming their oral bioavailability. They also show good bioactivity score for protease and enzyme inhibition. ADME/Tox studies conducted shows that almost all the derivatives are free from toxicity risks. It is observed that these mols. exhibit fairly good drug score and are orally viable mols. Chelation of chitosan and its derivatives with essential metal ions might be the mechanism driving their bioactivity. Thus chitosan monomer and the derivatives studied, can serve as good lead mols. for further research. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts