New manganese(II) and nickel(II) coordination compounds with N,O-polydentate ligands obtained from pyridoxal and tripodal units was written by Ebani, Patricia Regina;Fontana, Liniquer Andre;Campos, Patrick Teixeira;Rosso, Eduardo F.;Piquini, Paulo C.;Iglesias, Bernardo Almeida;Back, Davi Fernando. And the article was included in Journal of Molecular Structure in 2016.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
The authors have reported the synthesis involving the condensation of pyridoxal with tris(2-aminoethyl)amine obtained a tripodal ligand, as well as its subsequent complexation with the manganese(II) and nickel(II) ions. The structural anal. revealed, in the case of complex 1, the formation of a monomeric complex with Mn(II) species. In the complex 2, with Ni(II) metal ion, the authors describe the probable mechanism for the formation of hemiacetal in these complexes. Only the complex 1 catalyze the dismutation of superoxide efficiently with IC50 equal to 3.38 μM, evaluated through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. D. functional theory calculations are done to characterize and compare the mol. frontier orbitals of the Mn(II) and Ni(II) complexes. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
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