702-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 702-98-7, name is 2-Methyladamantan-2-ol, molecular formula is C11H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4.67 g (28 mmol) of 2-methyl-2-adamantanol, 2.77 g (35 mmol) of pyridine and 30 mL of drytetrahydrofuran were added to a 100 mL three-necked flask equipped with a drying tube containing calcium chloride and adropping funnel And the mixture was stirred with a magnetic stirrer under ice cooling. A dropping funnel was charged with asolution of 4.42 g (39 mmol) of chloroacetyl chloride in 10 mL of dry tetrahydrofuran. This chloroacetyl chloride solution wasadded dropwise over 15 minutes under ice cooling, then the reaction solution was heated to 20 C. and stirred for 22 hours. Inthe GC analysis at this point, 2-chloroacetoxy-2-methyladamantane was 64.2 area%. This solution was poured into a beakercontaining 300 mL of ion exchanged water, the resulting mixture was extracted three times with 100 mL of diethyl ether, and 20g of anhydrous sodium sulfate was added to the combined organic phases and dried. The chromaticity of the organic phase atthis point was APHA over 1000 degrees and it was orange colored. The desiccant was removed by filtration and thenconcentrated under reduced pressure to obtain 7.99 g of crude 2-chloroacetoxy-2-methyladamantane as a brown oil. Theresidue was purified by silica gel column chromatography (silica gel: Wakosil (registered trademark) C-200 (Wako PureChemical Industries, 64 g, elution solvent: hexane / diethyl ether = 10: 1)) to obtain 5.03 g of 2-chloroacetoxy-2-methyladamantane (74% yield) as an ultrathin pale yellow solid. Further, the chromaticity of the liquid state obtained by heating and melting the obtained solid was APHA of about 300 C, and was colored in a pale yellow color.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-98-7, 2-Methyladamantan-2-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NIPPON LIGHT METAL COMPANY LIMITED; TSUTSUI, HIDEYUKI; KATO, TOMOKI; TOYAMA, TAKASHI; (10 pag.)JP2018/127408; (2018); A;,
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