Selective sensing of nitric oxide by a 9,10-phenanthroquinone-pyridoxal based fluorophore was written by Maiti, Debjani;Islam, Abu Saleh Musha;Sasmal, Mihir;Prodhan, Chandraday;Ali, Mahammad. And the article was included in Photochemical & Photobiological Sciences in 2018.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
In this article, we have designed and synthesized a new, convenient and efficient phenanthroquinone-pyridoxal based fluorogenic probe PQPY, highly suitable for the selective and sensitive detection of nitric oxide in an aerated aqueous (7 : 3/H2O : MeCN) medium at pH 7.0 (10 mM HEPES buffer). Upon addition of nitric oxide, this probe exhibits emission in the green region (λem = 505 nm) which is ascribed to ICT (intramol. charge transfer) from the phenanthroquinone moiety to the imidazole -N-N=O fragment. The apparent formation constant, Kf, of the NO product of the ligand is (1.00 ± 0.2) × 105 M-1 and the LOD is 78 nM. The substantial enhancement of the life-time of the ligand (τ0 = 2.68 ns) occurs due to binding with nitric oxide (τ0 = 3.96 ns). This probe is low cytotoxicity, cell permeable and suitable for living cell imaging application. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
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