Perfluorohexyloctane (F6H8) as a delivery agent for cyclosporine A in dry eye syndrome therapy – Langmuir monolayer study complemented with infrared nanospectroscopy was written by Chachaj-Brekiesz, Anna;Wnetrzak, Anita;Lipiec, Ewelina;Kobierski, Jan;Dynarowicz-Latka, Patrycja. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2019.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:
One of the key challenges in dry eye syndrome therapy is to find a suitable carrier for immunosuppressant drug – cyclosporine A (CsA) – delivery to the eye. To investigate this issue, herein we present a methodol. based on the combined anal. in macro- (Langmuir monolayers), micro- (Brewster angle microscopy) and nanoscale (at. force microscopy and IR nano-spectroscopy). The applied approach proves that CsA affects the phospholipid part of the tear film lipid layer by loosening mol. packing. This effect can be reversed by the addition of perfluorohexyloctane (F6H8). We have highlighted that F6H8 increases the availability of CsA and therefore is appropriate carrier for CsA topical delivery to the eye in the dry eye syndrome. In addition, the applied herein procedure provides a simple, low-cost laboratory tool for preliminary studies involving membrane active pharmaceuticals, preceding in vivo tests. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate
Referemce:
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