Synthesis of 2-(Cyanomethyl)benzoic Esters via Carbon-Carbon Bond Cleavage of Indanones was written by Meng, Xiangtai;Chen, Dengfeng;Liu, Rui;Jiang, Ping;Huang, Shenlin. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 106-21-8 The following contents are mentioned in the article:
A novel synthesis of 2-(cyanomethyl)benzoic esters 2-C(R)CN-3-R1-4-R2-5-R3C6HC(O)OR4 (R = H, Me; R1 = H, Br, CN, CF3; R2 = H, Br, OMe, Cl, etc.; R3 = H, Me, OMe, Br; R4 = Me, Bn, furan-2-ylmethyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) and ethyl2-(3-cyanopropyl)benzoate from indanone derivatives I (R5 = Me, Ph, 4-trifluoromethylphenyl) and [5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-ylidene]amino acetate has been established. This reaction proceeds via a deprotonation of alcs. R4OH with a chem. base, followed by a nucleophilic addition to indanones I and Beckmann fragmentation. In addition, this reaction could also work under electrochem. conditions, and no external chem. bases were needed. This mild method offers a novel strategy for the late-stage functionalization of various natural alcs. such as citronellol, nerol, abietyl alc., etc. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8SDS of cas: 106-21-8).
3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 106-21-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts