Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C3H6O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C3H6O
A mixture of intermediate 525 (858 mg; 2.83 mmol), cyclopropanol (717 jiL; 11.3mmol) and cesium carbonate (1.84 g; 5.66 mmol) in 1,4-dioxane (9.5 mL) was heatedat 100C for 2h. The reaction mixture was heated at 100C overnight, cooled to roomtemperature and diluted with DCM. Water was added and the reaction mixture was extracted with DCM (three times). The combined organic layers were washed withwater, dried over MgSO4, filtered and evaporated to dryness. The residue was purified by chromatography over silica gel (irregular SiOH, 40 g; mobile phase: gradient from10% EtOAc, 90% heptane to 20% EtOAc, 80% heptane). The pure fractions were collected and evaporated to dryness yielding 581 mg (60%) of intermediate 526.
The synthetic route of 16545-68-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; PONCELET, Virginie Sophie; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (477 pag.)WO2017/125530; (2017); A1;,
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