Transition metal complexes with thiosemicarbazide-based ligands. Part 61. Comparative analysis of structural properties of the pyridoxal thiosemicarbazone ligands. Crystal structure of PLTSC·HCl·2H2O and its complex [Fe(PLTSC)Cl2(H2O)]Cl was written by Ivkovic, Sonja A.;Vojinovic-Jesic, Ljiljana S.;Leovac, Vukadin M.;Rodic, Marko V.;Novakovic, Sladjana B.;Bogdanovic, Goran A.. And the article was included in Structural Chemistry in 2015.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
A novel pyridoxal thiosemicarbazone (PLTSC) compound, exhibiting ligating properties, PLTSC·HCl·2H2O (1) was synthesized and characterized by x-ray anal. The PLTSC ligand 1 displays significantly different conformation in comparison to the five previously reported compounds of this type. The structural properties of six PLTSC ligands in different conformations were compared to establish the structural differences and understand the factors that facilitate particular conformations. The anal. indicated great structural flexibility of the PLTSC ligands. The PLTSC ligand 1 is essentially a planar mol. with the root-mean-square deviation of all non-H atoms equal to 0.06 Å. Consequently, the mols. of 1 form a layered three-dimensional structure which is stabilized by a variety of H bonds: O-H···O, O-H···N, O-H···Cl, O-H···S, N-H···O, N-H···N, N-H···Cl, N-H···S. The crystal structure of the Fe(III) complex with the ligand 1 [Fe(PLTSC)Cl2(H2O)]Cl was resolved by single-crystal x-ray anal. and structural properties of this octahedral complex are discussed and compared to those of uncoordinated PLTSC ligand. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts