As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4-(Dimethylamino)butan-1-ol
100 mg of intermediate compound 5 and 86 mg of triphosgene were dissolved in 10 ml of anhydrous dichloromethane, replaced with nitrogen three times, 0.12 ml of triethylamine was added under ice bath, and after 5 minutes, 0.12 ml of N,N-dimethylbutanol was dissolved in 10 ml of anhydrous dichloromethane, and added to the reaction solution, and reacted at room temperature overnight and TLC showed that the substrate completely disappeared. The reaction mixture was quenched and the reaction mixture was cooled to room temperature, the reaction mixture was extracted with ethyl acetate, the organic layer was washed with water three times, dried over anhydrous sodium sulfate, and concentrated, and subjected to column chromatography to obtain of 90 mg of yellow crystals (compound 1-1) (yield 64%).
With the rapid development of chemical substances, we look forward to future research findings about 13330-96-6.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Zuo Jianping; Lu Dong; Tong Xiankun; Zhang Yunzhe; Tang Wei; Ren Wenming; He Peilan; Chen Wuhong; Yang Xiaoqian; Zeng Limin; Yang Li; Liu Jianan; (61 pag.)CN109384727; (2019); A;,
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