With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2009-83-8, name is 6-Chlorohexan-1-ol, molecular formula is C6H13ClO, molecular weight is 136.6198, as common compound, the synthetic route is as follows.SDS of cas: 2009-83-8
In a 100 mL three-necked flask, 2.73 g (0.01 mol) of Compound 1 was dissolved in 50 mL of dry DMF,2.09 g (0.015 mol) of 6-chlorohexanol was added,3 g (0.022 mol) of anhydrous potassium carbonate and a catalytic amount of a phase transfer catalyst 18-crown-6,The reaction was carried out under the protection of nitrogen at a temperature of 100 C. for 12 hours;The solid in the solution obtained after the reaction was removed by filtration and the DMF was distilled off under reduced pressure. The resulting residue was separated by column chromatography (silica gel of 200 to 300 mesh was used as a stationary phase,The mobile phase consisted of a mixture of petroleum ether and ethyl acetate with a volume ratio of petroleum ether to ethyl acetate of 5: 1 to give 2.76 g of compound 2 (pale yellow solid, 74% yield)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2009-83-8, 6-Chlorohexan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Liu Xinhou; Si Peng; Zhen Zhen; Bo Shuhui; Deng Guowei; Huang Heyan; Peng Chengcheng; Xu Huajun; (23 pag.)CN104974151; (2017); B;,
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